Andrea Dovizioso (Ducati Team) took over at the top on his final push in FP4 at Misano, heading Maverick Viñales (Movistar Yamaha MotoGP) - who also improved on his final effort - and reigning Champion Marc Marquez (Repsol Honda Team).
There were a number of crashes, including an incident for Alvaro Bautista (Pull&Bear Aspar Team) and Hector Barbera (Reale Avintia Racing).
Next up is qualifying, with Q1 deciding two more entrants to the final top twelve shooutout in Q2.