Petrucci won the 2011 national Superstock Championship in his native Italy, as well as finishing runner up in the FIM Superstock 1000 Cup in the same year. A test rider for Ducati’s Superbike project, ‘Petrux’ then moved into MotoGP™ in 2012 with IodaRacing Project. In his second year the Italian scored points an impressive 11 times, and following recovery from a wrist injury, Petrucci then moved to Octo Pramac Yakhnich thereafter and then scored his first podium at Silverstone in 2015. 2016 was interrupted by injury, but the Italian showed his talent sufficiently to gain a 2017 Ducati for this season whilst remaining with Pramac - the only non-Ducati Team rider to have the new machine. 2017 was a breakout season, with numerous podiums and on occasion, threats at the victory. He stayed at the squad for 2018 and impressed once again, earning a seat at the factory Ducati Team for 2019. A run of nine-straight top six results saw Petrucci begin his factory career in fine style, with a fairy-tale maiden Grand Prix victory coming his way at Mugello, in between two P3s in Le Mans and Barcelona. A more difficult latter half of the season saw Petrucci slip from third to sixth in the overall standings. 2020 proved a challenging year on-track for the Italian as he failed to find the speed to consistenly challenge for the top places but he did have his moment also, securing victory in the rain in Le Mans, securing his second premier class victory. That was as good as it got though as he had to settle for 12th in the Championship. After a year at Red Bull KTM Tech3 in 2021, he left MotoGP™ and became a Dakar Rally stage winner, before reuniting with Ducati in MotoAmerica. In 2022, he made a late-season comeback to MotoGP™ when called upon by Team Suzuki Ecstar to fill in for the injured Joan Mir. Then, in 2023, the Italian stepped back into the factory Ducati seat at Le Mans to replace the injured Enea Bastianini.